miR-199a Overexpression Enhances the Potency of Human Induced-Pluripotent Stem-Cell-Derived Cardiomyocytes for Myocardial Repair

• Autori principali: Weihua Bian (Autore), Wangping Chen (Autore), Thanh Nguyen (Autore), Yang Zhou (Autore), Jianyi Zhang (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Mammalian cardiomyocytes exit the cell cycle during the perinatal period, and although cardiomyocytes differentiated from human induced-pluripotent stem cells (hiPSC-CMs) are phenotypically immature, their intrinsic cell-cycle activity remains limited. Thus, neither endogenous cardiomyocytes nor the...