Simultaneous determination of itraconazole and its CYP3A4-mediated metabolites including N-desalkyl itraconazole in human plasma using liquid chromatography-tandem mass spectrometry and its clinical application

• Κύριοι συγγραφείς: Yumi Imoto (Συγγραφέας), Yasuaki Mino (Συγγραφέας), Takafumi Naito (Συγγραφέας), Takaaki Ono (Συγγραφέας), Junichi Kawakami (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: BMC, 2020-05-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Background Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknown due to the lack of an accurate and reliable determination method....