Dual Inhibitors Targeting DNA and Histone Deacetylases
Histone deacetylases (HDACs) regulate the acetylation status of histones and structural status of chromatin. The chromatin structure becomes relaxed after inhibition of HDAC, leading to DNA exposed to DNA disrupting agents, and eventually causing DNA dysfunction. Recently, more and more dual inhibit...
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Georg Thieme Verlag KG,
2020-06-01T00:00:00Z.
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