Development and Evaluation of Docetaxel-Phospholipid Complex Loaded Self-Microemulsifying Drug Delivery System: Optimization and In Vitro/Ex Vivo Studies

• Main Authors: Miao Wang (Author), Sung-Kyun You (Author), Hong-Ki Lee (Author), Min-Gu Han (Author), Hyeon-Min Lee (Author), Thi Mai Anh Pham (Author), Young-Guk Na (Author), Cheong-Weon Cho (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Docetaxel (DTX) has clinical efficacy in the treatment of breast cancer, but it is difficult to develop a product for oral administration, due to low solubility and permeability. This study focused on preparing a self-microemulsifying drug delivery system (SME) loaded with DTX-phospholipid complex (...