Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans

• Main Authors: Yoo-Seong Jeong (Author), Min-Soo Kim (Author), Nora Lee (Author), Areum Lee (Author), Yoon-Jee Chae (Author), Suk-Jae Chung (Author), Kyeong-Ryoon Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fexuprazan is a new drug candidate in the potassium-competitive acid blocker (P-CAB) family. As proton pump inhibitors (PPIs), P-CABs inhibit gastric acid secretion and can be used to treat gastric acid-related disorders such as gastroesophageal reflux disease (GERD). Physiologically based pharmacok...