Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity

Can Chen,1,2,* Ting Wang,1,3,* Fengbo Wu,1,* Wei Huang,4 Gu He,1 Liang Ouyang,1 Mingli Xiang,1 Cheng Peng,4 Qinglin Jiang1,2 1State Key Laboratory of Biotherapy and Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 2College of Pharmacy and the First Affiliated Hospital, Cheng...

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Main Authors: Chen C (Author), Wang T (Author), Wu F (Author), Huang W (Author), He G (Author), Ouyang L (Author), Xiang M (Author), Peng C (Author), Jiang Q (Author)
Format: Book
Published: Dove Medical Press, 2014-09-01T00:00:00Z.
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