An Update on the Structure of hERG

• Main Authors: Andrew Butler (Author), Matthew V. Helliwell (Author), Yihong Zhang (Author), Jules C. Hancox (Author), Christopher E. Dempsey (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram. Inherited loss- or gain-of-function mutations in hERG can result in dangerous "long" (LQTS) or "short"...