Evaluation of the Effect of Food on the Pharmacokinetics of SHR6390, An Oral CDK4/6 Inhibitor, in Healthy Volunteers

• Main Authors: Yan-ping Liu (Author), Ming-hui Hu (Author), Ping-ping Lin (Author), Ting Li (Author), Shu-qin Liu (Author), Yu-ya Wang (Author), Shao-rong Li (Author), Xiang-kun Li (Author), Chen-jing Wang (Author), Yu Cao (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and Introduction SHR6390 is a new developed highly effective and selective small-molecule oral CDK4/6 inhibitor. We aimed to evaluate the effect of food on the pharmacokinetics of SHR6390 tablets. Methods In an open-label two-way crossover study, 24 healthy Chinese volunteers wer...