Evaluation of the Effect of Food on the Pharmacokinetics of SHR6390, An Oral CDK4/6 Inhibitor, in Healthy Volunteers

• Principais autores: Yan-ping Liu (Autor), Ming-hui Hu (Autor), Ping-ping Lin (Autor), Ting Li (Autor), Shu-qin Liu (Autor), Yu-ya Wang (Autor), Shao-rong Li (Autor), Xiang-kun Li (Autor), Chen-jing Wang (Autor), Yu Cao (Autor)
• Formato: Livro
• Publicado em: Adis, Springer Healthcare, 2022-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background and Introduction SHR6390 is a new developed highly effective and selective small-molecule oral CDK4/6 inhibitor. We aimed to evaluate the effect of food on the pharmacokinetics of SHR6390 tablets. Methods In an open-label two-way crossover study, 24 healthy Chinese volunteers wer...