Losartan Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation by Activating Ca2+-Activated K+ Channels in Mesenteric Artery From Type 2 Diabetic GK Rat

Losartan Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation by Activating Ca2+-Activated K+ Channels in Mesenteric Artery From Type 2 Diabetic GK Rat

Ca2+-activated K+ (K Ca ) channels are important for endothelium-derived hyperpolarizing factor (EDHF) signaling. Since treatment with angiotensin II receptor blockers (ARBs) improves vasculopathies in type 2 diabetic patients, we asked whether the EDHF-type relaxation and its associated K Ca channe...

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Main Authors: Takayuki Matsumoto (Author), Keiko Ishida (Author), Kumiko Taguchi (Author), Tsuneo Kobayashi (Author), Katsuo Kamata (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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