Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases

• Główni autorzy: Ioannis Gkekas (Autor), Anna Gioran (Autor), Marina Kleopatra Boziki (Autor), Nikolaos Grigoriadis (Autor), Niki Chondrogianni (Autor), Spyros Petrakis (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within the coding region of disease-causing genes. PolyQ-expanded proteins undergo conformational changes leading to the formation of protein inclusions which are associated with selective neuronal degene...