Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases

• Main Authors: Ioannis Gkekas (Author), Anna Gioran (Author), Marina Kleopatra Boziki (Author), Nikolaos Grigoriadis (Author), Niki Chondrogianni (Author), Spyros Petrakis (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within the coding region of disease-causing genes. PolyQ-expanded proteins undergo conformational changes leading to the formation of protein inclusions which are associated with selective neuronal degene...