Investigating the effect of dehydromiltirone on septic AKI using a network pharmacology method, molecular docking, and experimental validation

• Main Authors: Sijia Chen (Author), Yanzhe Wang (Author), Yuyuan Liu (Author), Linnan Bai (Author), Fengqin Li (Author), Yue Wu (Author), Xinmiao Xie (Author), Nan Zhang (Author), Chuchu Zeng (Author), Ling Zhang (Author), Xiaoxia Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury (AKI) is a severe and frequent complication of sepsis that occurs in intensive care units with inflammation and rapid decline in renal function as the main pathological features. Systemic inflammation, microvascular dysfunction, and tubule injury are the main causes of sepsis-ind...