Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response.

• Main Authors: Isabela Resende Pereira (Author), Glaucia Vilar-Pereira (Author), Otacilio Cruz Moreira (Author), Isalira Peroba Ramos (Author), Daniel Gibaldi (Author), Constança Britto (Author), Milton Ozório Moraes (Author), Joseli Lannes-Vieira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched myocarditis occurring in an inflammatory milieu. Pentoxifylline (PTX), a phosphodiesterase inhibitor, has immunoregulatory and cardioprot...