SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation

• Main Authors: Mingzhu Jiang (Author), Min Zhao (Author), Mi Bai (Author), Juan Lei (Author), Yanggang Yuan (Author), Songming Huang (Author), Yue Zhang (Author), Guixia Ding (Author), Zhanjun Jia (Author), Aihua Zhang (Author)
• Format: Book
• Published: Karger Publishers, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone. Silent mating type information regulation 2 homolog 1 (S...