Contribution of Bone Morphogenetic Protein-2 to Aortic Valve Calcification in Aged Rat

• Hoofdauteurs: Kazuhiko Seya (Auteur), Zaiqiang Yu (Auteur), Kouta Kanemaru (Auteur), Kazuyuki Daitoku (Auteur), Yui Akemoto (Auteur), Hiroyuki Shibuya (Auteur), Ikuo Fukuda (Auteur), Ken Okumura (Auteur), Shigeru Motomura (Auteur), Ken-Ichi Furukawa (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2011-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Although aging is well established as an important risk factor for aortic stenosis, the mechanism of age-related aortic valve calcification is yet unknown. Here, we investigated this mechanism in tissue and cellular levels using middle-aged rats. Aortic valve specimens were obtained by dissecting fr...