Contribution of Bone Morphogenetic Protein-2 to Aortic Valve Calcification in Aged Rat

• Main Authors: Kazuhiko Seya (Author), Zaiqiang Yu (Author), Kouta Kanemaru (Author), Kazuyuki Daitoku (Author), Yui Akemoto (Author), Hiroyuki Shibuya (Author), Ikuo Fukuda (Author), Ken Okumura (Author), Shigeru Motomura (Author), Ken-Ichi Furukawa (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although aging is well established as an important risk factor for aortic stenosis, the mechanism of age-related aortic valve calcification is yet unknown. Here, we investigated this mechanism in tissue and cellular levels using middle-aged rats. Aortic valve specimens were obtained by dissecting fr...