Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway

• Main Authors: Han-You Wu (Author), Xiang-Cheng Zhang (Author), Bing-Bing Jia (Author), Ye Cao (Author), Kai Yan (Author), Jing-Yuan Li (Author), Li Tao (Author), Zhi-Gang Jie (Author), Quan-Wen Liu (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to investigate the therapeutic potential of human umbilical cord mesenchymal stem cells derived exosomes (hUCMSC-Exo) in acute liver failure (ALF) in mice as well as its underlying mechanism. We found that a single tail vein administration of hucMSC-Exo effectively enhanced the surv...