Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses.

• Main Authors: Stefan W Metz (Author), Shaomin Tian (Author), Gabriel Hoekstra (Author), Xianwen Yi (Author), Michelle Stone (Author), Katie Horvath (Author), Michael J Miley (Author), Joseph DeSimone (Author), Chris J Luft (Author), Aravinda M de Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever. The virus is endemic in over 120 countries, causing over 350 million infections per year. Dengue vaccine development is challenging because of the need to induce simultaneous protection against four antigenicall...