Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

• Автори: Wagdy M. Eldehna (Автор), Hadia Almahli (Автор), Ghada H. Al-Ansary (Автор), Hazem A. Ghabbour (Автор), Mohamed H. Aly (Автор), Omnia E. Ismael (Автор), Abdullah Al-Dhfyan (Автор), Hatem A. Abdel-Aziz (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Treatment of patients with triple-negative breast cancer (TNBC) is challenging due to the absence of well- defined molecular targets and the heterogeneity of such disease. In our endeavor to develop potent isatin-based anti-proliferative agents, we utilized the hybrid-pharmacophore approach to synth...