Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria

Background: The novel bacterial topoisomerase inhibitors (NBTIs) developed in our laboratory show potent on-target enzyme inhibition but suffer from low activity against Gram-negative bacteria. Methods: With the aim of improving the antibacterial activity of our compounds against Gram-negative bacte...

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Main Authors: Maša Zorman (Author), Maja Kokot (Author), Irena Zdovc (Author), Lidija Senerovic (Author), Mina Mandic (Author), Nace Zidar (Author), Andrej Emanuel Cotman (Author), Martina Durcik (Author), Lucija Peterlin Mašič (Author), Nikola Minovski (Author), Marko Anderluh (Author), Martina Hrast Rambaher (Author)
Format: Book
Published: MDPI AG, 2024-11-01T00:00:00Z.
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