High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins C...

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Main Authors: Roderick G Walker (Author), Graeme Thomson (Author), Kirk Malone (Author), Matthew W Nowicki (Author), Elaine Brown (Author), David G Blake (Author), Nicholas J Turner (Author), Malcolm D Walkinshaw (Author), Karen M Grant (Author), Jeremy C Mottram (Author)
Format: Book
Published: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
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