Design, synthesis of new 2,4-thiazolidinediones: In-silico, in-vivo anti-diabetic and anti-inflammatory evaluation

• Main Authors: Shankar Gharge (Author), Shankar G. Alegaon (Author), Shriram D. Ranade (Author), N.A. Khatib (Author), Rohini S. Kavalapure (Author), B.R. Prashantha Kumar (Author), Vinod D (Author), Nandkishor B. Bavage (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a series of nine novel heterocyclic compounds were synthesized through a concise three-step reaction process. The synthesis involved Knoevenagel condensation at the 5th position of the 2,4-thiazolidinedione or rhodanine ring-system. Comprehensive physicochemical and spectral analyses,...