Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

• Main Authors: Christina A Bulman (Author), Chelsea M Bidlow (Author), Sara Lustigman (Author), Fidelis Cho-Ngwa (Author), David Williams (Author), Alberto A Rascón (Author), Nancy Tricoche (Author), Moses Samje (Author), Aaron Bell (Author), Brian Suzuki (Author), K C Lim (Author), Nonglak Supakorndej (Author), Prasit Supakorndej (Author), Alan R Wolfe (Author), Giselle M Knudsen (Author), Steven Chen (Author), Chris Wilson (Author), Kean-Hooi Ang (Author), Michelle Arkin (Author), Jiri Gut (Author), Chris Franklin (Author), Chris Marcellino (Author), James H McKerrow (Author), Anjan Debnath (Author), Judy A Sakanari (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for these diseases, but are mainly effective against t...