Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease

• Main Authors: Xiao-Gang Zhou (Author), Wen-Qiao Qiu (Author), Lu Yu (Author), Rong Pan (Author), Jin-Feng Teng (Author), Zhi-Pei Sang (Author), Betty Yuen-Kwan Law (Author), Ya Zhao (Author), Li Zhang (Author), Lu Yan (Author), Yong Tang (Author), Xiao-Lei Sun (Author), Vincent Kam Wai Wong (Author), Chong-Lin Yu (Author), Jian-Ming Wu (Author), Da-Lian Qin (Author), An-Guo Wu (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer's disease (AD). Microglial autophagic degradation not only decreases the deposits of extracellular Aβ fibrils but also inhibits the activation of NRLP3 inflam...