Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

• Main Authors: Laura Buyssens (Author), Laura De Clerck (Author), Wim Schelstraete (Author), Maarten Dhaenens (Author), Dieter Deforce (Author), Miriam Ayuso (Author), Chris Van Ginneken (Author), Steven Van Cruchten (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. Due to developmental changes in pharmacokinetics and pharmacodynamics, physiologically based pharmacokinetic (PBPK) models are built to better predict drug exposure in children and to a...