Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index

• Main Authors: Yanming Wang (Author), Fei Xie (Author), Lianqi Liu (Author), Xin Xu (Author), Shiyong Fan (Author), Wu Zhong (Author), Xinbo Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody-drug conjugates (ADCs) via the thiol-Michael click chemistry. Even so, the thiosuccinimide group produced in ADCs is unstable under physiological conditions, which is a unresolved issue in the ADC...