Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4

• Main Authors: Qiji Li (Author), Min Wang (Author), Leli Zeng (Author), Wei Guo (Author), Yuandong Xu (Author), Chenxin Li (Author), Yingrong Lai (Author), Liping Ye (Author), Xinsheng Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Management of patients with prostate cancer and bone metastatic disease remains a major clinical challenge. Loss or mutation of p53 has been identified to be involved in the tumor progression and metastasis. Nevertheless, direct evidence of a specific role for wild-type p53 (wt-p53) in b...