Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity

• Main Authors: Yasuhiko Izumi (Author), Noriyuki Yamamoto (Author), Sayaka Matsushima (Author), Takamori Yamamoto (Author), Yuki Takada-Takatori (Author), Akinori Akaike (Author), Toshiaki Kume (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and the ubiquitin-proteasome system play a key role in the pathogenesis of Parkinson disease. Although the herbicide paraquat is an environmental factor that is involved in the etiology of Parkinson disease, the role of 26S proteasome in paraquat toxicity remains to be determined. U...