Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

• Main Authors: Wenyue Zheng (Author), Erkang Tian (Author), Zhen Liu (Author), Changhan Zhou (Author), Pei Yang (Author), Keyue Tian (Author), Wen Liao (Author), Juan Li (Author), Changyu Ren (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the renin-angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides. Angiotensin-converting-enzyme inhibitors (ACE inhibitors, ACEIs) decrease the formation of angiotensin II and increase the l...