Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.

• Main Authors: Lívia de Figueiredo Diniz (Author), Julio A Urbina (Author), Isabel Mayer de Andrade (Author), Ana Lia Mazzeti (Author), Tassiane Assíria F Martins (Author), Ivo Santana Caldas (Author), André Talvani (Author), Isabela Ribeiro (Author), Maria Terezinha Bahia (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasi...