The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

• Main Authors: Simona Saponara (Author), Fabio Fusi (Author), Ottavia Spiga (Author), Alfonso Trezza (Author), Brian Hopkins (Author), Margaret A. Brimble (Author), David Rennison (Author), Sergio Bova (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction. The current study was undertaken to verify this hypothesis by comparing the effe...