Inhibition of MurA Enzyme from <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> by Diterpenes from <i>Lepechinia meyenii</i> and Their Synthetic Analogs

• Main Authors: Macarena Funes Chabán (Author), Martina Hrast (Author), Rok Frlan (Author), Dafni G. Graikioti (Author), Constantinos M. Athanassopoulos (Author), María Cecilia Carpinella (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enzymes MurA and MurF, involved in bacterial cell wall synthesis, have been validated as targets for the discovery of novel antibiotics. A panel of plant-origin antibacterial diterpenes and synthetic analogs derived therefrom were investigated for their inhibitory properties on these enzymes from &l...