Pharmacological inhibition of STAT3 by BP‐1‐102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response

• প্রধান লেখক: Zhixian Jiang (লেখক), Jiaxin Huang (লেখক), Lingtong You (লেখক), Jinning Zhang (লেখক), Bingyu Li (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2021-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract As an inhibitor of STAT3, BP‐1‐102 can regulate the inflammation response caused by vascular smooth muscle cells (VSMCs) by inhibiting the JAK/STAT3/NF‐κB pathway, thereby attenuating the symptoms of intracranial aneurysm (IA). IA mouse model was established by stereotactic injection of ela...