SP1 Promotes HDAC4 Expression and Inhibits HMGB1 Expression to Reduce Intestinal Barrier Dysfunction, Oxidative Stress, and Inflammatory Response after Sepsis

• Main Authors: Zhen-Mi Liu (Author), Xi Wang (Author), Chen-Xi Li (Author), Xue-Yan Liu (Author), Xiao-Jing Guo (Author), Yang Li (Author), You-Lian Chen (Author), Hong-Xing Ye (Author), Huai-Sheng Chen (Author)
• Format: Book
• Published: Karger Publishers, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism of specificity protein-1 (SP1) in the development of sepsis. A mouse model of sepsis was established by cecal ligation p...