Synthesis and Preclinical Evaluation of Novel ⁶⁸Ga-Labeled (<i>R</i>)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging

• Váldodahkkit: Shreya Bendre (Dahkki), Hsiou-Ting Kuo (Dahkki), Helen Merkens (Dahkki), Zhengxing Zhang (Dahkki), Antonio A. W. L. Wong (Dahkki), François Bénard (Dahkki), Kuo-Shyan Lin (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2023-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy of carcinomas. Here, we synthesized two novel (&...