Synthesis and Preclinical Evaluation of Novel ⁶⁸Ga-Labeled (<i>R</i>)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging

• Príomhchruthaitheoirí: Shreya Bendre (Údar), Hsiou-Ting Kuo (Údar), Helen Merkens (Údar), Zhengxing Zhang (Údar), Antonio A. W. L. Wong (Údar), François Bénard (Údar), Kuo-Shyan Lin (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2023-05-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy of carcinomas. Here, we synthesized two novel (&...