Synthesis and Preclinical Evaluation of Novel ⁶⁸Ga-Labeled (<i>R</i>)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging

• Main Authors: Shreya Bendre (Author), Hsiou-Ting Kuo (Author), Helen Merkens (Author), Zhengxing Zhang (Author), Antonio A. W. L. Wong (Author), François Bénard (Author), Kuo-Shyan Lin (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy of carcinomas. Here, we synthesized two novel (&...