Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

• Main Authors: Alison E. Fohner (Author), Rachel Dalton (Author), Kasse Skagen (Author), Konner Jackson (Author), Katrina G. Claw (Author), Scarlett E. Hopkins (Author), Renee Robinson (Author), Burhan A. Khan (Author), Bhagwat Prasad (Author), Erin G. Schuetz (Author), Deborah A. Nickerson (Author), Timothy A. Thornton (Author), Denise A. Dillard (Author), Bert B. Boyer (Author), Kenneth E. Thummel (Author), Erica L. Woodahl (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet,...