Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

• প্রধান লেখক: Alison E. Fohner (লেখক), Rachel Dalton (লেখক), Kasse Skagen (লেখক), Konner Jackson (লেখক), Katrina G. Claw (লেখক), Scarlett E. Hopkins (লেখক), Renee Robinson (লেখক), Burhan A. Khan (লেখক), Bhagwat Prasad (লেখক), Erin G. Schuetz (লেখক), Deborah A. Nickerson (লেখক), Timothy A. Thornton (লেখক), Denise A. Dillard (লেখক), Bert B. Boyer (লেখক), Kenneth E. Thummel (লেখক), Erica L. Woodahl (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2021-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet,...