Metformin Reverses <i>tmexCD1-toprJ1</i>- and <i>tet</i>(A)-Mediated High-Level Tigecycline Resistance in <i>K. pneumoniae</i>

• Main Authors: Xia Xiao (Author), Quanmin Huan (Author), Yanhu Huang (Author), Yuan Liu (Author), Ruichao Li (Author), Xilan Xu (Author), Zhiqiang Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tigecycline (TIG) is one of the last effective options against multidrug resistance bacteria. Recently, the RND (resistance-nodulation-division) efflux pump gene cluster, <i>tmexCD1-toprJ1</i>, and the tetracycline-efflux pump <i>tet</i>(A) mutation were reported to mediate h...