Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1

• Main Authors: Mingxing Hu (Author), Weilin Zhou (Author), Yijie Wang (Author), Dongping Yao (Author), Tinghong Ye (Author), Yuqin Yao (Author), Bin Chen (Author), Gongping Liu (Author), Xifei Yang (Author), Wei Wang (Author), Yongmei Xie (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple cancers. Indoleamine 2,3-dioxygenase 1 (IDO1), an immune checkpoint, plays an important role in tumor immune escape through the regulation of multiple immune cells and has been rega...