A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition

• Main Authors: Srinivasan Chinnapaiyan (Author), Maria-Jose Santiago (Author), Kingshuk Panda (Author), Md. Sohanur Rahman (Author), Jessica Alluin (Author), John Rossi (Author), Hoshang J. Unwalla (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene editing using clustered regularly interspaced short palindromic repeats (CRISPR) targeted to HIV proviral DNA has shown excision of HIV from infected cells. However, CRISPR-based HIV excision is vulnerable to viral escape. Targeting cellular co-factors provides an attractive yet risky alternati...