Alternative splicing of UCP1 by non-cell-autonomous action of PEMT

• Main Authors: Jordan M. Johnson (Author), Anthony R.P. Verkerke (Author), J. Alan Maschek (Author), Patrick J. Ferrara (Author), Chien-Te Lin (Author), Kimberly A. Kew (Author), P. Darrell Neufer (Author), Irfan J. Lodhi (Author), James E. Cox (Author), Katsuhiko Funai (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking PEMT (PEMTKO) are cold-intolerant when fed a high-fat diet (HFD) due t...