Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

• Main Authors: Wei Meng (Author), Adnana Paunel-Görgülü (Author), Sascha Flohé (Author), Ingo Witte (Author), Michael Schädel-Höpfner (Author), Joachim Windolf (Author), Tim Tobias Lögters (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determined the relationship of NETs and DNase after majo...