Efficient Delivery of P3H4 siRNA and Chlorin e6 by cRGDfK-Installed Polyarginine Nanoparticles for Tumor-Targeting Therapy of Bladder Cancer

• Main Authors: Lin Hao (Author), Zhenduo Shi (Author), Yang Dong (Author), Jiangang Chen (Author), Kun Pang (Author), Houguang He (Author), Shaoqi Zhang (Author), Wei Wu (Author), Qianjin Zhang (Author), Conghui Han (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Prolyl 3-hydroxylase family member 4 (P3H4) is a potent prognostic oncogene in bladder cancer (BC), and the inhibition of P3H4 suppresses BC tumor growth. This study aimed to evaluate the efficiency of P3H4 inhibition for BC tumor therapy via tumor-targeting nanoparticles. Methods and resul...