Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle

• Main Authors: Wanshan Feng (Author), Chaolong Qin (Author), Elena Cipolla (Author), Jong Bong Lee (Author), Atheer Zgair (Author), Yenju Chu (Author), Catherine A. Ortori (Author), Michael J. Stocks (Author), Cris S. Constantinescu (Author), David A. Barrett (Author), Peter M. Fischer (Author), Pavel Gershkovich (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of lipid-bas...