HLA-A2 and B35 restricted hantaan virus nucleoprotein CD8+ T-cell epitope-specific immune response correlates with milder disease in hemorrhagic fever with renal syndrome.

• Main Authors: Ying Ma (Author), Jiuping Wang (Author), Bin Yuan (Author), Meiliang Wang (Author), Yun Zhang (Author), Zhuwei Xu (Author), Chunmei Zhang (Author), Yusi Zhang (Author), Bei Liu (Author), Jing Yi (Author), Kun Yang (Author), Angang Yang (Author), Ran Zhuang (Author), Boquan Jin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Hantaan virus (HTNV) infection in humans is a serious public health concern in Asia. A potent T cell activation peptide vaccine from HTNV structure protein represents a promising immunotherapy for disease control. However, the T cell epitopes of the HTNV restricted by the HLA alleles and...