HLA-A2 and B35 restricted hantaan virus nucleoprotein CD8+ T-cell epitope-specific immune response correlates with milder disease in hemorrhagic fever with renal syndrome.

• Автори: Ying Ma (Автор), Jiuping Wang (Автор), Bin Yuan (Автор), Meiliang Wang (Автор), Yun Zhang (Автор), Zhuwei Xu (Автор), Chunmei Zhang (Автор), Yusi Zhang (Автор), Bei Liu (Автор), Jing Yi (Автор), Kun Yang (Автор), Angang Yang (Автор), Ran Zhuang (Автор), Boquan Jin (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND: Hantaan virus (HTNV) infection in humans is a serious public health concern in Asia. A potent T cell activation peptide vaccine from HTNV structure protein represents a promising immunotherapy for disease control. However, the T cell epitopes of the HTNV restricted by the HLA alleles and...