Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells

• Main Authors: Yueh-Lun Lee (Author), Che-Jen Hsiao (Author), Fan-Li Lin (Author), Jing-Shiun Jan (Author), Yung-Chen Chou (Author), Yen-Yu Lin (Author), Chih-Kuang Chen (Author), Kwok-Keung Lam (Author), George Hsiao (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Much evidence has indicated that matrix metalloproteinases (MMPs) participate in the progression of neuroinflammatory disorders. The present study was undertaken to investigate the inhibitory effect and mechanism of the antipsychotic haloperidol on MMP activation in the stimulated THP-1 monocytic ce...