Global estrogen receptor-α knockout has differential effects on cortical and cancellous bone in aged male mice

• Main Authors: Rebecca K. Dirkes (Author), Nathan C. Winn (Author), Thomas J. Jurrissen (Author), Dennis B. Lubahn (Author), Victoria J. Vieira-Potter (Author), Jaume Padilla (Author), Pamela S. Hinton (Author)
• Format: Book
• Published: Canadian Science Publishing, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estrogen receptor-α knockout (ERKO) in female rodents results in bone loss associated with increased osteocyte sclerostin expression; whether this also occurs in males is unknown. Here, we examined the effects of ERKO on femoral cortical geometry, trabecular microarchitecture, and osteocyte sclerost...