Combining non-negative matrix factorization with graph Laplacian regularization for predicting drug-miRNA associations based on multi-source information fusion

• Päätekijät: Mei-Neng Wang (Tekijä), Yu Li (Tekijä), Li-Lan Lei (Tekijä), De-Wu Ding (Tekijä), Xue-Jun Xie (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Increasing evidences suggest that miRNAs play a key role in the occurrence and progression of many complex human diseases. Therefore, targeting dysregulated miRNAs with small molecule drugs in the clinical has become a new treatment. Nevertheless, it is high cost and time-consuming for identifying m...