mitoTALEN reduces the mutant mtDNA load in neurons

mitoTALEN reduces the mutant mtDNA load in neurons

Mutations within mtDNA frequently give rise to severe encephalopathies. Given that a majority of these mtDNA defects exist in a heteroplasmic state, we harnessed the precision of mitochondrial-targeted TALEN (mitoTALEN) to selectively eliminate mutant mtDNA within the CNS of a murine model harboring...

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Main Authors: Sandra R. Bacman (Author), Jose Domingo Barrera-Paez (Author), Milena Pinto (Author), Derek Van Booven (Author), James B. Stewart (Author), Anthony J. Griswold (Author), Carlos T. Moraes (Author)
Format: Book
Published: Elsevier, 2024-03-01T00:00:00Z.
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