mitoTALEN reduces the mutant mtDNA load in neurons
Mutations within mtDNA frequently give rise to severe encephalopathies. Given that a majority of these mtDNA defects exist in a heteroplasmic state, we harnessed the precision of mitochondrial-targeted TALEN (mitoTALEN) to selectively eliminate mutant mtDNA within the CNS of a murine model harboring...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2024-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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