CD28 Aptamers as Powerful Immune Response Modulators

• Main Authors: Fernando Pastor (Author), Mario M Soldevilla (Author), Helena Villanueva (Author), Despina Kolonias (Author), Susana Inoges (Author), Ascensión L de Cerio (Author), Romy Kandzia (Author), Victor Klimyuk (Author), Yuri Gleba (Author), Eli Gilboa (Author), Maurizio Bendandi (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor. As a monomer, one of them interfered with the binding of CD28 to its ligand (B7), precluding the costimulatory signal, whereas the oth...