Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis

• Main Authors: Shahira F. El Menshawe (Author), Khaled Shalaby (Author), Mohammed H. Elkomy (Author), Heba M. Aboud (Author), Yasmin M. Ahmed (Author), Abdelmeged A. Abdelmeged (Author), Marwa Elkarmalawy (Author), Mahmoud A. Abou Alazayem (Author), Amani M. El Sisi (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low bioavailability and cardiovascular side effects remain the major challenges that limit its exploitation. In this work, we developed ultra-elastic nanov...