Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

• Hauptverfasser: Alaa Elwan (Verfasst von), Helmy Sakr (Verfasst von), Abdel-Ghany (Verfasst von), Ahmed El-morsy (Verfasst von), Mohamed A. Abdelgawad (Verfasst von), Mohammed M. Ghoneim (Verfasst von), Mohamed El-Sherbiny (Verfasst von), Khaled El-Adl (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c and 7b exhibited the highest anticancer activitie...