Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

• Auteurs principaux: Alaa Elwan (Auteur), Helmy Sakr (Auteur), Abdel-Ghany (Auteur), Ahmed El-morsy (Auteur), Mohamed A. Abdelgawad (Auteur), Mohammed M. Ghoneim (Auteur), Mohamed El-Sherbiny (Auteur), Khaled El-Adl (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c and 7b exhibited the highest anticancer activitie...